In the last twenty years or so, research has emerged that supports the idea that boosting levels of NAD+ (the oxidized form of nicotinamide adenine dinucleotide) in animals (including mammals) can slow or even reverse many aspects of biological aging, either by activating sirtuins (proteins that regulate key biological pathways), by facilitating cell-to-cell and intracellular communication, and/or by other means. NAD+ levels can be boosted by orally supplementing with NAD+ precursors, including nicotinamide riboside (patented and marketed as Niagen, abbreviated as NR), and nicotinamide mononucleotide (abbreviated as NMN). To a much lesser extent, NAD+ can be increased by supplementing with plain old niacinamide/nicotinamide (NAM), and niacin/nicotinic acid (NA).
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I’ve been sleeping better–much better–and it feels like a good time to do a complete roundup of all the methods that appear to have helped me, and also mention a few sacred cows of sleep tips that didn’t seem to help at all. For those of you new to this blog, my sleep went to hell in mid-January after the deaths of two family members within a single week. It’s been a slow climb back to a more-or-less normal sleep pattern ever since. Here’s what worked:
I saw two dead bodies in the same week, and I stopped sleeping.
The first body was my father-in-law, at his viewing. He looked natural, as if peacefully asleep. But his total stillness betrayed this illusion.
My uncle died a week later, at an assisted living facility in Concord. He’d been estranged from our family for more than twenty years, but he’d reached out recently, and we were all getting to know each other again. He’d been ill for a long time, with COPD, but that week he had a stroke, and died a few days later. The morning he died, my mom and I drove to Concord, and waited in his room for the mortician. My uncle was emaciated, and pale, and obviously dead, but still warm. I helped move his body from his bed to the gurney. He weighed almost nothing.
There are a few supplements I take regularly, including conservative amounts of vitamin D and fish oil (both of which help keep me free of asthma symptoms). Recently I’ve added 25-50mg of niacinamide (also known as nicotinamide, a form of vitamin B3, similar to niacin but without the flushing side effect) a few times a week to my regimen. Here are the reasons why:
Winston Churchill’s nicknamed depression “his black dog.”
A week ago I woke up in a black mood. Instead of feeling excited about my day, I saw a series of dreary tasks ahead of me. Looking into the future, I felt despair instead of hopefulness. Things that usually bring me great pleasure (making music, time with my family and friends, drinking coffee) seemed a little less bright.