In the last twenty years or so, research has emerged that supports the idea that boosting levels of NAD+ (the oxidized form of nicotinamide adenine dinucleotide) in animals (including mammals) can slow or even reverse many aspects of biological aging, either by activating sirtuins (proteins that regulate key biological pathways), by facilitating cell-to-cell and intracellular communication, and/or by other means. NAD+ levels can be boosted by orally supplementing with NAD+ precursors, including nicotinamide riboside (patented and marketed as Niagen, abbreviated as NR), and nicotinamide mononucleotide (abbreviated as NMN). To a much lesser extent, NAD+ can be increased by supplementing with plain old niacinamide/nicotinamide (NAM), and niacin/nicotinic acid (NA).
